論文 - 詳細
| RRC ID | 57976 |
|---|---|
| 著者 | Sheikh Mohamed M, Poulose AC, Veeranarayanan S, Romero Aburto R, Mitcham T, Suzuki Y, Sakamoto Y, Ajayan PM, Bouchard RR, Yoshida Y, Maekawa T, Sakthi Kumar D. |
| タイトル | Plasmonic fluorescent CdSe/Cu2S hybrid nanocrystals for multichannel imaging and cancer directed photo-thermal therapy. |
| ジャーナル | Nanoscale |
| Abstract |
A simple, crude Jatropha curcas (JC) oil-based synthesis approach, devoid of any toxic phosphine and pyrophoric ligands, to produce size and shape tuned CdSe QDs and a further copper sulfide (Cu2S) encasing is presented. The QDs exhibited excellent photoluminescent properties with narrow band gap emission. Furthermore, the Cu2S shell rendered additional cytocompatibility and stability to the hybrid nanomaterial, which are major factors for translational and clinical applications of QDs. The nanocomposites were PEGylated and folate conjugated to augment their cytoamiability and enhance their specificity towards cancer cells. The nanohybrids possess potentials for visible, near infrared (NIR), photoacoustic (PA) and computed tomography (μCT) imaging. The diverse functionality of the composite was derived from the multi-channel imaging abilities and thermal competence on NIR laser irradiation to specifically actuate the photo-thermal ablation of brain cancer cells. |
| 巻・号 | 8(15) |
| ページ | 7876-88 |
| 公開日 | 2016-4-21 |
| DOI | 10.1039/c5nr05225d |
| PMID | 26584976 |
| MeSH | Animals Cadmium Compounds Cell Line, Tumor Copper Humans Hyperthermia, Induced / methods* Jatropha Mice Nanocomposites / chemistry Nanocomposites / therapeutic use Nanoparticles / chemistry* Nanoparticles / therapeutic use* Nanoparticles / ultrastructure Nanotechnology Neoplasms / diagnostic imaging* Neoplasms / therapy* Phantoms, Imaging Phototherapy / methods* Plant Oils Quantum Dots / chemistry Quantum Dots / therapeutic use Quantum Dots / ultrastructure Selenium Compounds Spectroscopy, Fourier Transform Infrared Sulfides X-Ray Microtomography |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | human brain glioblastoma |