RRC ID 58
Author Ogino T, Moralejo DH, Kose H, Yamada T, Matsumoto K.
Title Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity.
Journal Mamm. Genome
Abstract Leptin is produced by adipose tissue and acts as a feedback signal to the hypothalamus controlling energy homeostasis, by reducing food consumption and increasing energy expenditure. Because serum leptin levels are highly correlated with body fat mass, they can be used as an index to predict obesity-related diseases. However, the identity of genetic factors that influence the obesity and the obesity-related metabolic disorders remains largely unknown. In this study, we performed a whole-genome scan search, using 382 F2 intercross progeny between the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model for obese type 2 diabetes in human, and F344 rat, in order to identify loci responsible for the regulation of leptin and other obesity-related plasma substances. We have identified two quantitative trait loci (QTLs) contributing to serum leptin levels. These two loci, designated Olep1 [Chromosome (Chr) 2] and Olep2 (Chr 6), were homologous to those of human genome regions containing several potential candidate genes for obesity. These are fatty acid-binding protein 2 (FABP2), FABP4, and FABP5 for Olep1, and proopiomelanocortin (POMC) and glucose regulatory protein (GCKR) for Olep2.
Volume 14(12)
Pages 839-44
Published 2003-12
DOI 10.1007/s00335-003-2295-7
PMID 14724732
MeSH Adaptor Proteins, Signal Transducing Animals Carrier Proteins / genetics Chromosome Mapping Chromosomes, Mammalian / genetics* Crosses, Genetic Diabetes Mellitus, Type 2 / genetics* Disease Models, Animal Enzyme-Linked Immunosorbent Assay Fatty Acid-Binding Proteins Humans Leptin / blood* Lod Score Microsatellite Repeats / genetics Obesity / genetics* Pro-Opiomelanocortin / genetics Quantitative Trait Loci* Rats Rats, Inbred F344 Rats, Inbred OLETF Synteny / genetics
IF 2.687
Times Cited 13
WOS Category BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Rats