Reference - Detail
| RRC ID | 58023 |
|---|---|
| Author | Tang R, Kimishima A, Ishida R, Setiawan A, Arai M. |
| Title | Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation. |
| Journal | J Nat Med |
| Abstract |
The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together with structurally related compounds, trichodermamide A (2) and aspergillazine A (3), were isolated from culture extract of marine-derived Trichoderma lixii. Compounds 1 exhibited potent selective cytotoxic activity against human pancreatic carcinoma PANC-1 cells cultured under glucose-starved conditions with IC50 values of 0.02 µM. The selective index of the compound 1 was found to be 35,500-fold higher for cells cultured under glucose-starved conditions than those under the general culture conditions. The mechanistic analysis indicated that compound 1 inhibited the response of the ER stress signaling. In addition, these effects of compound 1 could be mediated by inhibiting complex II in the mitochondrial electron transport chain. |
| Volume | 74(1) |
| Pages | 153-158 |
| Published | 2020-1-1 |
| DOI | 10.1007/s11418-019-01357-w |
| PII | 10.1007/s11418-019-01357-w |
| PMID | 31435860 |
| PMC | PMC7946679 |
| MeSH | Antineoplastic Agents / pharmacology* Cell Line, Tumor Dipeptides / chemistry Dipeptides / pharmacology* Electron Transport / drug effects Glucose / metabolism Growth Inhibitors / pharmacology Humans Mitochondria / metabolism Neoplasms / drug therapy* Piperazines / pharmacology* Trichoderma / chemistry* Tumor Microenvironment |
| IF | 2.055 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | PANC-1(RCB2095) |