Reference - Detail
| RRC ID | 58028 |
|---|---|
| Author | Okuda-Hanafusa C, Uchio R, Fuwa A, Kawasaki K, Muroyama K, Yamamoto Y, Murosaki S. |
| Title | Turmeronol A and turmeronol B from Curcuma longa prevent inflammatory mediator production by lipopolysaccharide-stimulated RAW264.7 macrophages, partially via reduced NF-κB signaling. |
| Journal | Food Funct |
| Abstract |
Chronic inflammation depends on inflammatory mediators produced by activated macrophages and is the common pathological basis for various diseases. Turmeronol is a sesquiterpenoid found in the spice turmeric (Curcuma longa), which is known to have anti-inflammatory activity. To elucidate the anti-inflammatory mechanism of turmeronol, we investigated the influence of turmeronol A and turmeronol B in mouse macrophages (RAW264.7 cells) stimulated with lipopolysaccharide (LPS). Pretreatment of RAW264.7 cells with either turmeronol A or B significantly inhibited LPS-induced production of prostaglandin E2 and nitric oxide, as well as expression of mRNAs for the corresponding synthetic enzymes. In addition, the turmeronols significantly inhibited LPS-induced upregulation of interleukin-1β, interleukin-6, and tumor necrosis factor-α at the mRNA and protein levels. Both turmeronols also inhibited nuclear translocation of nuclear factor κB (NF-κB), with a similar time course to the NF-κB inhibitor pyrrolidine dithiocarbamate, but not curcumin (another NF-κB inhibitor). Thus, both turmeronols prevented activation of macrophages and inflammatory mediator production, possibly by suppressing activation of NF-κB, and therefore have potential for use in preventing chronic inflammatory diseases. |
| Volume | 10(9) |
| Pages | 5779-5788 |
| Published | 2019-9-1 |
| DOI | 10.1039/c9fo00336c |
| PMID | 31454011 |
| MeSH | Animals Anti-Inflammatory Agents / pharmacology* Curcuma / chemistry* Dinoprostone / immunology Inflammation / drug therapy Inflammation / genetics Inflammation / immunology* Inflammation Mediators / immunology Interleukin-6 / genetics Interleukin-6 / immunology Lipopolysaccharides / adverse effects Macrophages / drug effects* Macrophages / immunology Mice NF-kappa B / genetics NF-kappa B / immunology* Nitric Oxide / immunology Plant Extracts / pharmacology* RAW 264.7 Cells Sesquiterpenes / pharmacology* Tumor Necrosis Factor-alpha / genetics Tumor Necrosis Factor-alpha / immunology |
| IF | 4.171 |
| Times Cited | 0 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |