| RRC ID |
58042
|
| 著者 |
Kharaghani D, Gitigard P, Ohtani H, Kim KO, Ullah S, Saito Y, Khan MQ, Kim IS.
|
| タイトル |
Design and characterization of dual drug delivery based on in-situ assembled PVA/PAN core-shell nanofibers for wound dressing application.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Core-shell nanofibers with the ability to carry multiple drugs are attracting the attention to develop appropriate drug delivery systems for wounds dressing applications. In this study, biocompatible core-shell nanofibers have been designed as a promising dual-drug carrier with the capability of delivering both water-soluble and organic solvent-soluble drugs simultaneously. With the aim of fabricating the core-shell nanofibers, the dipping method has been employed. For this propose, core nanofibers made from polyvinyl alcohol (PVA) were immersed in various concentrations of polyacrylonitrile (PAN) and cross-linked by dipping into ethanol. Diclofenac sodium salt (DSs) and gentamicin sulfate (GENs) have been loaded into the core and shell nanofibers as models of the drug, respectively. The morphology study of core-shell nanofibers showed that the concentrations between 1% w/w up to 2% w/w PAN/GENs, with deep penetration into the internal layers of PAV/DSs nanofibers could lead to the core-shell structure. The cytotoxicity results showed the competency of designed core-shell nanofibers for wound dressing application. Also, the release profile exhibits the controllable behavior of drug release.
|
| 巻・号 |
9(1)
|
| ページ |
12640
|
| 公開日 |
2019-9-2
|
| DOI |
10.1038/s41598-019-49132-x
|
| PII |
10.1038/s41598-019-49132-x
|
| PMID |
31477774
|
| PMC |
PMC6718412
|
| MeSH |
Acrylic Resins / chemistry*
Bandages*
Cell Adhesion / drug effects
Cell Death / drug effects
Cross-Linking Reagents / chemistry
Diclofenac / pharmacology
Diclofenac / therapeutic use
Drug Delivery Systems*
Drug Liberation
Nanofibers / chemistry*
Nanofibers / ultrastructure
Photoelectron Spectroscopy
Polyvinyl Alcohol / chemistry*
Spectroscopy, Fourier Transform Infrared
Temperature
Thermogravimetry
Wounds and Injuries / drug therapy*
|
| IF |
3.998
|
| 引用数 |
3
|
| リソース情報 |
| ヒト・動物細胞 |
NIH3T3-3-4(RCB1862) |
