RRC ID 58059
著者 Choi S, Cha PH, Kim HY, Choi KY.
タイトル Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway.
ジャーナル Exp Mol Med
Abstract Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height enhancement is limited to growth hormone treatment, which often results in side effects and clinical failure and is costly. Although recent studies have indicated the importance of paracrine signals in the growth plate for longitudinal bone growth, height-stimulating agents targeting the signaling pathways involved in growth plate maturation remain unavailable in the clinic. The Wnt/β-catenin pathway plays a major role in the maturation of growth plate chondrocytes. In this study, by using an ex vivo tibial culture system, we identified indirubin-3'-oxime (I3O) as a compound capable of enhancing longitudinal bone growth. I3O promoted chondrocyte proliferation and differentiation via activation of the Wnt/β-catenin pathway in vitro. Intraperitoneal injection of I3O in adolescent mice increased growth plate height along with incremental chondrocyte maturation. I3O promoted tibial growth without significant adverse effects on bone thickness and articular cartilage. Therefore, I3O could be a potential therapeutic agent for increasing height in children with growth retardation.
巻・号 51(9)
ページ 1-10
公開日 2019-9-12
DOI 10.1038/s12276-019-0306-3
PII 10.1038/s12276-019-0306-3
PMID 31515471
PMC PMC6802626
MeSH Animals Bone Development / drug effects* Bone Development / genetics Cell Differentiation / drug effects Cell Proliferation / drug effects Chondrocytes / drug effects Chondrogenesis / drug effects* Glycogen Synthase Kinase 3 beta / antagonists & inhibitors Glycogen Synthase Kinase 3 beta / genetics* Growth Disorders / drug therapy Growth Disorders / genetics Growth Plate / drug effects Humans Indoles / pharmacology* Mice Osteogenesis / drug effects Oximes / pharmacology* Wnt Signaling Pathway / drug effects beta Catenin / genetics
IF 5.418
引用数 0
リソース情報
ヒト・動物細胞 ATDC5(RCB0565)