Reference - Detail
|Author||Kikuchi S, Noguchi K, Wakai K, Hamazaki Y, Tozawa K, Jomori T, Sasako M, Miwa H.|
|Title||Propagermanium Induces NK Cell Maturation and Tends to Prolong Overall Survival of Patients With Refractory Cancer.|
BACKGROUND/AIM:Propagermanium (PG) inhibits the CCL2/CCR2 axis, and has been shown to function as an immune modulator. This study investigated its anti-tumor mechanism in patients with refractory cancers.
MATERIALS AND METHODS:Five healthy volunteers and 23 patients with refractory oral (n=8) or gastric (n=15) cancer received PG (30 mg/day). We performed flow cytometry (FCM) of peripheral blood mononuclear cells and in vitro killing assays.
RESULTS:FCM revealed that CD16+/CD56Dim NK cells (i.e., mature, cytolytic subset) increased, and the apoptosis induction rate of cancer cells increased after PG administration. Among gastric cancer patients, median OS was 172.0 days. Two patients showed complete remission of lung or liver metastasis. Survival of patients with oral cancer also tended to be prolonged.
CONCLUSION:PG induces NK cell maturation, and may potentiate anti-tumor activity.
|MeSH||Antineoplastic Agents / pharmacology* Cell Differentiation / drug effects* Cell Differentiation / immunology* Cell Line, Tumor Drug Resistance, Neoplasm Humans Kaplan-Meier Estimate Killer Cells, Natural / drug effects* Killer Cells, Natural / immunology* Leukocytes, Mononuclear / drug effects Leukocytes, Mononuclear / immunology Leukocytes, Mononuclear / metabolism Lymphocyte Subsets / immunology Lymphocyte Subsets / metabolism Neoplasms / diagnosis Neoplasms / drug therapy Neoplasms / immunology* Neoplasms / mortality* Organometallic Compounds / pharmacology* Tomography, X-Ray Computed|
|Human and Animal Cells||HeLa(RCB0007)|