| RRC ID |
58082
|
| 著者 |
Matsuo H, Nakanishi J, Noguchi Y, Kitagawa K, Shigemura K, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T.
|
| タイトル |
Nanaomycin K, a new epithelial-mesenchymal transition inhibitor produced by the actinomycete "Streptomyces rosa subsp. notoensis" OS-3966.
|
| ジャーナル |
J Biosci Bioeng
|
| Abstract |
A new nanaomycin analog, nanaomycin K, was isolated from a cultured broth of actinomycete strain "Streptomyces rosa subsp. notoensis" OS-3966. Nuclear magnetic resonance (NMR) analyses revealed that the planar structure of nanaomycin K had an ergothioneine moiety. To determine the absolute configuration, nanaomycin K was semisynthesized using standards of nanaomycin E and l-ergothioneine. The natural and semisynthetic nanaomycin K were identified as the same compounds based on retention time, mass spectrometry, 1H NMR, and optical rotation data. Nanaomycin K showed cytotoxicity against Madin-Darby canine kidney (MDCK) cells undergoing transforming growth factor (TGF) β1-induced epithelial-mesenchymal transition.
|
| 巻・号 |
129(3)
|
| ページ |
291-295
|
| 公開日 |
2020-3-1
|
| DOI |
10.1016/j.jbiosc.2019.09.007
|
| PII |
S1389-1723(19)30811-4
|
| PMID |
31582334
|
| MeSH |
Animals
Cell Line
Cell Proliferation / drug effects*
Dogs
Epithelial-Mesenchymal Transition / drug effects*
Naphthoquinones / chemistry
Naphthoquinones / metabolism
Naphthoquinones / pharmacology*
Streptomyces / metabolism*
|
| IF |
2.366
|
| リソース情報 |
| ヒト・動物細胞 |
MDCK(RCB0995) |
