| RRC ID |
5812
|
| 著者 |
Tsuda S, Kitagawa T, Takashima S, Asakawa S, Shimizu N, Mitani H, Shima A, Tsutsumi M, Hori H, Naruse K, Ishikawa Y, Takeda H.
|
| タイトル |
FAK-mediated extracellular signals are essential for interkinetic nuclear migration and planar divisions in the neuroepithelium.
|
| ジャーナル |
J Cell Sci
|
| Abstract |
During the development of the vertebrate nervous system, mitosis of neural progenitor cells takes place near the lumen, the apical side of the neural tube, through a characteristic movement of nuclei known as interkinetic nuclear migration (INM). Furthermore, during the proliferative period, neural progenitor cells exhibit planar cell divisions to produce equivalent daughter cells. Here, we examine the potential role of extracellular signals in INM and planar divisions using the medaka mutant tacobo (tab). This tab mutant shows pleiotropic phenotypes, including neurogenesis, and positional cloning identified tab as laminin gamma1 (lamc1), providing a unique framework to study the role of extracellular signals in neurogenesis. In tab mutant neural tubes, a number of nuclei exhibit abnormal patterns of migration leading to basally mislocalized mitosis. Furthermore, the orientation of cell division near the apical surface is randomized. Probably because of these defects, neurogenesis is accelerated in the tab neural tube. Detailed analyses demonstrate that extracellular signals mediated by the FAK pathway regulate INM and planar divisions in the neuroepithelium, possibly through interaction with the intracellular dynein-motor system.
|
| 巻・号 |
123(Pt 3)
|
| ページ |
484-96
|
| 公開日 |
2010-2-1
|
| DOI |
10.1242/jcs.057851
|
| PII |
jcs.057851
|
| PMID |
20067997
|
| MeSH |
Animals
Cell Nucleus / metabolism*
Fish Proteins / metabolism*
Immunoblotting
Immunohistochemistry
Microscopy, Confocal
Neuroepithelial Cells / cytology
Neuroepithelial Cells / metabolism*
Oryzias
Signal Transduction / physiology*
|
| IF |
4.573
|
| 引用数 |
24
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| メダカ |
d-rR/TOKYO (MT837)
tab (MT166) |
