| RRC ID |
58129
|
| 著者 |
Ju N, Shimamura M, Hayashi H, Ikeda Y, Yoshida S, Nakamura A, Morishita R, Rakugi H, Nakagami H.
|
| タイトル |
Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.
|
| ジャーナル |
Sci Rep
|
| Abstract |
We recently developed a partial peptide of receptor activator of nuclear factor-кB ligand (RANKL) known as microglial healing peptide 1 (MHP1-AcN), that inhibits Toll-like receptor (TLR)-related inflammation through RANKL/RANK signaling in microglia and macrophages without promoting osteoclast activation. The abnormal activation of TLRs contributes to the initiation and maintenance of psoriasis, which is a chronic inflammatory skin disease that involves the aberrant expression of proinflammatory cytokines and the subsequent dermal γδ T cell and T helper 17 (Th17) cell responses. The inhibition of TLR-mediated inflammation provides an important strategy to treat psoriasis. Here, we examined the preventative effects of MHP1-AcN in a mouse model of imiquimod (a TLR 7/8 agonist)-induced psoriasis. Topical imiquimod application induced psoriasis-like skin lesions on the ear and dorsal skin. Systemic administration of MHP1-AcN by daily subcutaneous injection significantly prevented the development of skin lesions, including erythema, scaling and thickening. Mice treated with MHP1-AcN showed reduced levels of skin Il6 mRNA at 32 h and reduced levels of Il23 and Il17a mRNA at d9. Serum levels of IL-6 and IL-23 were reduced at 32 h, and IL-17A was reduced at d9. These results indicated that MHP1-AcN could decrease imiquimod-induced IL-6, IL-23 and IL-17A production. MHP1-AcN is potentially an alternative treatment for psoriasis.
|
| 巻・号 |
9(1)
|
| ページ |
15434
|
| 公開日 |
2019-10-28
|
| DOI |
10.1038/s41598-019-51681-0
|
| PII |
10.1038/s41598-019-51681-0
|
| PMID |
31659208
|
| PMC |
PMC6817907
|
| MeSH |
Animals
Cytokines / immunology*
Disease Models, Animal
Imiquimod / toxicity*
Male
Mice
Mice, Inbred BALB C
Peptides / chemistry
Peptides / pharmacology*
Psoriasis* / chemically induced
Psoriasis* / immunology
Psoriasis* / pathology
Psoriasis* / prevention & control
RANK Ligand / chemistry*
|
| IF |
3.998
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
