論文 - 詳細
| RRC ID | 58295 |
|---|---|
| 著者 | Wei M, Shi L, Kong R, Zhao H, Li Z. |
| タイトル | Heparan sulfate maintains adult midgut homeostasis in Drosophila. |
| ジャーナル | Cell Biol Int |
| Abstract |
Tissue homeostasis is controlled by the differentiated progeny of residential progenitors (stem cells). Adult stem cells constantly adjust their proliferation/differentiation rates to respond to tissue damage and stresses. However, how differentiated cells maintain tissue homeostasis remains unclear. Here, we find that heparan sulfate (HS), a class of glycosaminoglycan (GAG) chains, protects differentiated cells from loss to maintain intestinal homeostasis. HS depletion in enterocytes (ECs) leads to intestinal homeostasis disruption, with accumulation of intestinal stem cell (ISC)-like cells and mis-differentiated progeny. HS-deficient ECs are prone to cell death/stress and induced cytokine and epidermal growth factor (EGF) expression, which, in turn, promote ISC proliferation and differentiation. Interestingly, HS depletion in ECs results in the inactivation of decapentaplegic (Dpp) signaling. Moreover, ectopic Dpp signaling completely rescued the defects caused by HS depletion. Together, our data demonstrate that HS is required for Dpp signal activation in ECs, thereby protecting ECs from ablation to maintain midgut homeostasis. Our data shed light into the regulatory mechanisms of how differentiated cells contribute to tissue homeostasis maintenance. |
| 巻・号 | 44(3) |
| ページ | 905-917 |
| 公開日 | 2020-3-1 |
| DOI | 10.1002/cbin.11289 |
| PMID | 31868274 |
| MeSH | Adult Stem Cells / cytology Adult Stem Cells / metabolism Animals Cell Death Cell Differentiation Cell Proliferation Cytokines / metabolism Drosophila / metabolism* Drosophila Proteins / metabolism Enterocytes / cytology Enterocytes / metabolism* Epidermal Growth Factor / metabolism Female Heparan Sulfate / physiology* Homeostasis* Intestines / cytology |
| IF | 2.571 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |