Reference - Detail
| RRC ID | 58324 |
|---|---|
| Author | Yang X, Liang J, Ding L, Li X, Lam SM, Shui G, Ding M, Huang X. |
| Title | Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. |
| Journal | PLoS Genet |
| Abstract |
Phosphatidylserine (PS), synthesized in the endoplasmic reticulum (ER) by phosphatidylserine synthase (PSS), is transported to the plasma membrane (PM) and mitochondria through distinct routes. The in vivo functions of PS at different subcellular locations and the coordination between different PS transport routes are not fully understood. Here, we report that Drosophila PSS regulates cell growth, lipid storage and mitochondrial function. In pss RNAi, reduced PS depletes plasma membrane Akt, contributing to cell growth defects; the metabolic shift from phospholipid synthesis to neutral lipid synthesis results in ectopic lipid accumulation; and the reduction of mitochondrial PS impairs mitochondrial protein import and mitochondrial integrity. Importantly, reducing PS transport from the ER to PM by loss of PI4KIIIα partially rescues the mitochondrial defects of pss RNAi. Together, our results uncover a balance between different PS transport routes and reveal that PSS regulates cellular homeostasis through distinct metabolic mechanisms. |
| Volume | 15(12) |
| Pages | e1008548 |
| Published | 2019-12-1 |
| DOI | 10.1371/journal.pgen.1008548 |
| PII | PGENETICS-D-19-00778 |
| PMID | 31869331 |
| PMC | PMC6946173 |
| MeSH | Animals CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase / metabolism* CDPdiacylglycerol-Serine O-Phosphatidyltransferase / metabolism* Cell Membrane / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Endoplasmic Reticulum / metabolism* Homeostasis Mitochondria / metabolism Phosphatidylserines / metabolism* Protein Transport Proto-Oncogene Proteins c-akt / metabolism |
| IF | 5.175 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 4825R-1 4825R-3 |