RRC ID 58398
Author Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG.
Title Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
Journal Cell Rep
Abstract The laminar architecture of the mammalian neocortex depends on the orderly generation of distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. Here, we identify critical roles for the autism risk gene Foxp1 in maintaining aRG identity and gating the temporal competency for deep-layer neurogenesis. Early in development, aRG express high levels of Foxp1 mRNA and protein, which promote self-renewing cell divisions and deep-layer neuron production. Foxp1 levels subsequently decline during the transition to superficial-layer neurogenesis. Sustained Foxp1 expression impedes this transition, preserving a population of cells with aRG identity throughout development and extending the early neurogenic period into postnatal life. FOXP1 expression is further associated with the initial formation and expansion of basal RG (bRG) during human corticogenesis and can promote the formation of cells exhibiting characteristics of bRG when misexpressed in the mouse cortex. Together, these findings reveal broad functions for Foxp1 in cortical neurogenesis.
Volume 30(6)
Pages 1964-1981.e3
Published 2020-2-11
DOI 10.1016/j.celrep.2020.01.034
PII S2211-1247(20)30049-8
PMID 32049024
PMC PMC8397815
MeSH Animals Cell Differentiation / physiology Cell Self Renewal / physiology Forkhead Transcription Factors / metabolism* Humans Mice Neural Stem Cells / cytology Neural Stem Cells / metabolism* Repressor Proteins / metabolism*
IF 8.109
Times Cited 1
Mice RBRC01342 RBRC01343