RRC ID 5842
著者 Kato M, Takehana Y, Sakaizumi M, Hamaguchi S.
タイトル A sex-determining region on the Y chromosome controls the sex-reversal ratio in interspecific hybrids between Oryzias curvinotus females and Oryzias latipes males.
ジャーナル Heredity (Edinb)
Abstract Oryzias latipes and Oryzias curvinotus are closely related medaka species that have the common sex-determining gene, DMY, on their homologous Y chromosomes. We previously reported that sex-reversed XY females were produced in hybrids between O. curvinotus females and O. latipes males (Hd-rR inbred strain). In this study we used HNI inbred strain males of O. latipes for mating with O. curvinotus females, and found that all the XY hybrids developed as males. To map the factor responsible for this strain-specific XY sex reversal, O. curvinotus females were mated with two Y-congenic strains (HNI.Y(Hd-rR) and Hd-rR.Y(HNI)) and a recombinant congenic strain (Hd-rR.Y(HNI)rr). HNI.Y(Hd-rR) produced sex-reversed females in the XY hybrids, whereas no sex-reversed females were obtained in the XY hybrids from Hd-rR.Y(HNI) and Hd-rR.Y(HNI)rr, demonstrating that a small region on the Y chromosome, which includes DMY, is responsible for the XY sex reversal. Sex-reversed hybrids were only produced in the presence of the Y-chromosomal region derived from the Hd-rR strain, suggesting that missense or regulatory mutations specific to the Hd-rR Y-chromosomal region induce the sex reversal.
巻・号 104(2)
ページ 191-5
公開日 2010-2-1
DOI 10.1038/hdy.2009.114
PII hdy2009114
PMID 19756038
MeSH Animals Chromosome Mapping Female Fish Proteins / genetics Hermaphroditic Organisms* Inbreeding Male Oryzias / genetics* Oryzias / physiology Sex Determination Processes* Y Chromosome / genetics*
IF 3.436
引用数 7
WOS 分野 GENETICS & HEREDITY ECOLOGY EVOLUTIONARY BIOLOGY
リソース情報
メダカ Hd-rR.Y^HNI (MT191) Hd-rR.Y^HNIrr (MT197) Oryzias curvinotus HdrR-II1 (IB178) HNI-II (IB176) HO4C (IB180)