RRC ID 58475
著者 Hao X, Wang S, Lu Y, Yu W, Li P, Jiang D, Guo T, Li M, Li J, Xu J, Wu W, Ho MS, Zhang L.
タイトル Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling.
ジャーナル Elife
Abstract Tissue homeostasis and regeneration in the Drosophila midgut is regulated by a diverse array of signaling pathways including the Hippo pathway. Hippo signaling restricts intestinal stem cell (ISC) proliferation by sequestering the transcription co-factor Yorkie (Yki) in the cytoplasm, a factor required for rapid ISC proliferation under injury-induced regeneration. Nonetheless, the mechanism of Hippo-mediated midgut homeostasis and whether canonical Hippo signaling is involved in ISC basal proliferation are less characterized. Here we identify Lola as a transcription factor acting downstream of Hippo signaling to restrict ISC proliferation in a Yki-independent manner. Not only that Lola interacts with and is stabilized by the Hippo signaling core kinase Warts (Wts), Lola rescues the enhanced ISC proliferation upon Wts depletion via suppressing Dref and SkpA expressions. Our findings reveal that Lola is a non-canonical Hippo signaling component in regulating midgut homeostasis, providing insights on the mechanism of tissue maintenance and intestinal function.
巻・号 9
公開日 2020-1-14
DOI 10.7554/eLife.47542
PII 47542
PMID 31934851
PMC PMC7299341
MeSH Animals Cell Differentiation Cell Proliferation Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Female Gene Expression Regulation* Green Fluorescent Proteins / metabolism Homeostasis* Intestines / cytology* Intracellular Signaling Peptides and Proteins / metabolism* Nuclear Proteins / metabolism Protein Kinases / metabolism Protein Serine-Threonine Kinases / metabolism* RNA-Seq SKP Cullin F-Box Protein Ligases / metabolism Signal Transduction Stem Cells / cytology Trans-Activators / metabolism Transcription Factors / genetics Transcription Factors / metabolism* YAP-Signaling Proteins
IF 7.08
引用数 0
リソース情報
ショウジョウバエ 12052R-1