論文 - 詳細
| RRC ID | 58492 |
|---|---|
| 著者 | Morioka S, Mohanty-Hejmadi P, Yaoita Y, Tazawa I. |
| タイトル | Homeotic transformation of tails into limbs in anurans. |
| ジャーナル | Dev Growth Differ |
| Abstract |
Anuran tadpoles can regenerate their tails after amputation. However, they occasionally form ectopic limbs instead of the lost tail part after vitamin A treatment. This is regarded as an example of a homeotic transformation. In this phenomenon, the developmental fate of the tail blastema is apparently altered from that of a tail to that of limbs, indicating a realignment of positional information in the blastema. Morphological observations and analyses of the development of skeletal elements during the process suggest that positional information in the blastema is rewritten from tail to trunk specification under the influence of vitamin A, resulting in limb formation. Despite the extensive information gained from morphological observations, a comprehensive understanding of this phenomenon also requires molecular data. We review previous studies related to anuran homeotic transformation. The findings of these studies provide a basis for evaluating major hypotheses and identifying molecular data that should be prioritized in future studies. Finally, we argue that positional information for the tail blastema changes to that for a part of the trunk, leading to homeotic transformations. To suggest this hypothesis, we present published data that favor the rewriting of positional information. |
| 巻・号 | 60(6) |
| ページ | 365-376 |
| 公開日 | 2018-8-1 |
| DOI | 10.1111/dgd.12547 |
| PMID | 30133711 |
| MeSH | Animals Anura Hindlimb / growth & development* Larva / growth & development Morphogenesis* Tail / growth & development* |
| IF | 1.723 |
| 引用数 | 4 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| ツメガエル・イモリ | |