論文 - 詳細
| RRC ID | 58495 |
|---|---|
| 著者 | Bamunusinghe D, Skorski M, Buckler-White A, Kozak CA. |
| タイトル | Xenotropic Mouse Gammaretroviruses Isolated from Pre-Leukemic Tissues Include a Recombinant. |
| ジャーナル | Viruses |
| Abstract |
Naturally-occurring lymphomagenesis is induced by mouse leukemia viruses (MLVs) carried as endogenous retroviruses (ERVs). Replicating the ecotropic MLVs recombines with polytropic (P-ERVs) and xenotropic ERVs (X-ERVs) to generate pathogenic viruses with an altered host range. While most recovered nonecotropic recombinants have a polytropic host range, the X-MLVs are also present in the pre-leukemic tissues. We analyzed two such isolates from the AKR mice to identify their ERV progenitors and to look for evidence of recombination. AKR40 resembles the active X-ERV Bxv1, while AKR6 has a Bxv1-like backbone with substitutions that alter the long terminal repeat (LTR) enhancer and the envelope (env). AKR6 has a modified xenotropic host range, and its Env residue changes all lie outside of the domain that governs the receptor choice. The AKR6 segment spanning the two substitutions, but not the entire AKR6 env-LTR, exists as an ERV, termed Xmv67, in AKR, but not in the C57BL/6 mice. This suggests that AKR6 is the product of one, not two, recombination events. Xmv67 originated in the Asian mice. These data indicate that the recombinant X-MLVs that can be generated during lymphomagenesis, describe a novel X-ERV subtype found in the AKR genome, but not in the C57BL/6 reference genome, and identify residues in the envelope C-terminus that may influence the host range. |
| 巻・号 | 10(8) |
| 公開日 | 2018-8-9 |
| DOI | 10.3390/v10080418 |
| PII | v10080418 |
| PMID | 30096897 |
| PMC | PMC6116186 |
| MeSH | Animals Endogenous Retroviruses / genetics* Evolution, Molecular* Gammaretrovirus / genetics* Gammaretrovirus / isolation & purification Genome, Viral Host Specificity Leukemia Virus, Murine / genetics* Leukemia Virus, Murine / isolation & purification Lymphoma / virology* Mice Mice, Inbred AKR Mice, Inbred C57BL Receptors, Virus / genetics Recombination, Genetic* Terminal Repeat Sequences |
| IF | 3.811 |
| 引用数 | 1 |
| リソース情報 | |
| 遺伝子材料 | Genomic DNA of Mouse M.MUS-NJL RBRC00207 (RDB06977) Genomic DNA of Mouse STM1 RBRC00265 (RDB06981) Genomic DNA of Mouse STM2 RBRC00266 (RDB06982) Genomic DNA of Mouse Mol-KOR5/Stm RBRC00428 (RDB06983) Genomic DNA of Mouse Mol-KOR7/Stm RBRC00429 (RDB06984) Genomic DNA of Mouse Mol-AIZ/Stm RBRC00430 (RDB06985) Genomic DNA of Mouse Mol-Mae/Stm RBRC00431 (RDB06986) Genomic DNA of Mouse HMI/Ms RBRC00657 (RDB06989) Genomic DNA of Mouse MYS/Mz RBRC01196 (RDB06993) Genomic DNA of Mouse Akt/TUA RBRC01238 (RDB06994) Genomic DNA of Mouse IRK/TUA RBRC01241 (RDB15854) Genomic DNA of Mouse Tom/TUA RBRC01243 (RDB15863) Genomic DNA of Mouse KNB/TUA RBRC01247 (RDB15860) Genomic DNA of Mouse Ast/TUA RBRC01249 (RDB06995) Genomic DNA of Mouse MOM RBRC01837 (RDB06996) Genomic DNA of Mouse CASP/1Nga RBRC03108 (RDB15834) |