論文 - 詳細
| RRC ID | 58586 |
|---|---|
| 著者 | Park E, Kim J, Yeo S, Lim E, Choi CW, Choi S, Li WY, Lee JW, Park JH, Huh D, Jeong SY. |
| タイトル | Anti-Osteoporotic Effects of Combined Extract of Lycii Radicis Cortex and Achyranthes japonica in Osteoblast and Osteoclast Cells and Ovariectomized Mice. |
| ジャーナル | Nutrients |
| Abstract |
Osteoporosis is characterized by low bone density and quality with high risk of bone fracture. Here, we investigated anti-osteoporotic effects of natural plants (Lycii Radicis Cortex (LRC) and Achyranthes japonica (AJ)) in osteoblast and osteoclast cells in vitro and ovariectomized mice in vivo. Combined LRC and AJ enhanced osteoblast differentiation and mineralized bone-forming osteoblasts by the up-regulation of bone metabolic markers (Alpl, Runx2 and Bglap) in the osteoblastic cell line MC3T3-E1. However, LRC and AJ inhibited osteoclast differentiation of monocytes isolated from mouse bone marrow. In vivo experiments showed that treatment of LRC+AJ extract prevented OVX-induced trabecular bone loss and osteoclastogenesis in an osteoporotic animal model. These results suggest that LRC+AJ extract may be a good therapeutic agent for the treatment and prevention of osteoporotic bone loss. |
| 巻・号 | 11(11) |
| 公開日 | 2019-11-9 |
| DOI | 10.3390/nu11112716 |
| PII | nu11112716 |
| PMID | 31717518 |
| PMC | PMC6893723 |
| MeSH | Achyranthes / chemistry* Animals Bone Density Conservation Agents* / chemistry Bone Density Conservation Agents* / pharmacology Cell Line Drugs, Chinese Herbal / chemistry* Female Mice Osteoblasts / drug effects Osteoclasts / drug effects Osteogenesis / drug effects* Osteoporosis / metabolism Ovariectomy Plant Extracts* / chemistry Plant Extracts* / pharmacology |
| IF | 4.546 |
| 引用数 | 1 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |