RRC ID 58599
Author Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M.
Title Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review.
Journal Dis Markers
Abstract Backgrounds:The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies.
Methods:A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo.
Results:The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision.
Conclusion:All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose.
Volume 2019
Pages 8040361
Published 2019-1-1
DOI 10.1155/2019/8040361
PMID 31019584
PMC PMC6452537
MeSH Biomarkers, Tumor / genetics* Biomarkers, Tumor / metabolism Carcinoma / genetics* Carcinoma / metabolism Carcinoma / pathology Clinical Trials as Topic Evaluation Studies as Topic* Humans Mouth Neoplasms / genetics* Mouth Neoplasms / metabolism Mouth Neoplasms / pathology
IF 2.761
Times Cited 18
Resource
Human and Animal Cells HSC-2(RCB1945) HSC-3(RCB1975) HSC-4(RCB1902) Ca9-22(RCB1976) Sa3(RCB0980) HO-1-u-1(RCB2102)