| RRC ID |
58610
|
| 著者 |
Tamai M, Uchisawa H, Saito Y, Matsue H, Kawase M, Naraoka T, Tagawa YI.
|
| タイトル |
Acorbine, a Corbicula japonica-derived tripeptide containing non-proteinogenic amino acids, suppresses ethanol-induced liver injury.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Since ancient times, Corbicula extract has been believed in Japan to have hepatoprotective effects, but it remains unclear whether these claims are true, and if so, which component is responsible for hepatoprotection. In this study, we showed that Corbicula extract exerted a protective effect against liver damage. Recent work identified acorbine (β-alanyl-ornithyl-ornithine), a novel tripeptide containing non-proteinogenic amino acids, in the extract of Corbicula japonica. Synthesized acorbine cured alcohol-induced liver damage in mice. In addition, acorbine purified from Corbicula extract exerted a protective effect against alcohol-induced hepatotoxicity in a culture liver model derived from mouse ES/iPS cells. Thus, acorbine is one of the components of Corbicula extract that protects hepatocytes against ethanol-induced death.
|
| 巻・号 |
522(3)
|
| ページ |
580-584
|
| 公開日 |
2020-2-12
|
| DOI |
10.1016/j.bbrc.2019.11.131
|
| PII |
S0006-291X(19)32259-4
|
| PMID |
31784088
|
| MeSH |
Alcohol Drinking / adverse effects
Animals
Cell Death / drug effects
Chemical and Drug Induced Liver Injury, Chronic / drug therapy*
Chemical and Drug Induced Liver Injury, Chronic / etiology
Chemical and Drug Induced Liver Injury, Chronic / pathology
Corbicula / chemistry*
Cytoprotection / drug effects
Ethanol / adverse effects
Female
Hepatocytes / drug effects
Hepatocytes / pathology
Mice, Inbred C57BL
Peptides / chemistry
Peptides / therapeutic use*
Plant Extracts / chemistry
Plant Extracts / therapeutic use*
Protective Agents / chemistry
Protective Agents / therapeutic use*
|
| IF |
2.985
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
iPS-MEF-Ng-20D-17(APS0001) |
