| RRC ID |
58623
|
| Author |
Miyaji H, Mayumi K, Miyata S, Nishida E, Shitomi K, Hamamoto A, Tanaka S, Akasaka T.
|
| Title |
Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler.
|
| Journal |
Dent Mater J
|
| Abstract |
Surface pre-reacted glass-ionomer (S-PRG) filler releases several ions, such as fluoride, borate and strontium ions, to exert bioactive effects. We fabricated an endodontic root canal sealer containing S-PRG fillers (S-PRG sealer) and then evaluated the antibacterial and anti-inflammatory properties of S-PRG sealer compared with sealer containing conventional silica fillers (silica sealer). Antibacterial tests showed that S-PRG sealer significantly reduced the turbidity of Enterococcus faecalis compared with silica sealer. Implantation of S-PRG or silica sealer blocks in rat subcutaneous tissue showed that S-PRG sealer decreased the proinflammatory response compared with silica sealer at 10 days post-implantation. In addition, immunostaining revealed that infiltration of CD68- and peroxidase-positive cells around the S-PRG sealer was significantly lower than that in silica sealer. Therefore, it was suggested that S-PRG sealer exhibits antibacterial and anti-inflammatory effects.
|
| Volume |
39(2)
|
| Pages |
287-294
|
| Published |
2020-3-31
|
| DOI |
10.4012/dmj.2019-029
|
| PMID |
31776316
|
| MeSH |
Animals
Dental Pulp Cavity*
Fluorides
Glass Ionomer Cements*
Rats
Silicon Dioxide
|
| IF |
1.359
|
| Times Cited |
1
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
