RRC ID |
58632
|
Author |
Hitora Y, Takada K, Ise Y, Woo SP, Inoue S, Mori N, Takikawa H, Nakamukai S, Okada S, Matsunaga S.
|
Title |
Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression.
|
Journal |
Bioorg Med Chem
|
Abstract |
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.
|
Volume |
28(2)
|
Pages |
115233
|
Published |
2020-1-15
|
DOI |
10.1016/j.bmc.2019.115233
|
PII |
S0968-0896(19)31782-1
|
PMID |
31848114
|
MeSH |
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Cycle / drug effects
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Molecular Structure
Porifera / chemistry*
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Structure-Activity Relationship
Tumor Cells, Cultured
|
IF |
3.073
|
Times Cited |
0
|
Resource |
Human and Animal Cells |
HeLa/Fucci2(RCB2867) |