RRC ID 58753
Author Sarmales-Murga C, Akaoka F, Sato M, Takanishi J, Mino T, Miyoshi N, Watanabe K.
Title A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity.
Journal J Antibiot (Tokyo)
Abstract Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC50 of 17.3 µM. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).
Volume 73(5)
Pages 320-323
Published 2020-5-1
DOI 10.1038/s41429-020-0281-x
PII 10.1038/s41429-020-0281-x
PMID 32024969
MeSH Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Benzopyrans / chemistry Benzopyrans / isolation & purification Benzopyrans / pharmacology* Chaetomium / chemistry* Female HeLa Cells Humans Inhibitory Concentration 50 Pigments, Biological / chemistry Pigments, Biological / isolation & purification Pigments, Biological / pharmacology* Uterine Cervical Neoplasms / drug therapy*
IF 2.446
Times Cited 0
Human and Animal Cells HeLa