| RRC ID |
58753
|
| 著者 |
Sarmales-Murga C, Akaoka F, Sato M, Takanishi J, Mino T, Miyoshi N, Watanabe K.
|
| タイトル |
A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC50 of 17.3 µM. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).
|
| 巻・号 |
73(5)
|
| ページ |
320-323
|
| 公開日 |
2020-5-1
|
| DOI |
10.1038/s41429-020-0281-x
|
| PII |
10.1038/s41429-020-0281-x
|
| PMID |
32024969
|
| MeSH |
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Benzopyrans / chemistry
Benzopyrans / isolation & purification
Benzopyrans / pharmacology*
Chaetomium / chemistry*
Female
HeLa Cells
Humans
Inhibitory Concentration 50
Pigments, Biological / chemistry
Pigments, Biological / isolation & purification
Pigments, Biological / pharmacology*
Uterine Cervical Neoplasms / drug therapy*
|
| IF |
2.446
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa |
