Reference - Detail
| RRC ID | 58769 |
|---|---|
| Author | Krishnan M, Hwang JS, Kim M, Kim YJ, Seo JH, Jung J, Ha E. |
| Title | β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice. |
| Journal | Nutrients |
| Abstract |
β-hydroxybutyrate (β-OHB) has been shown to exert an anti-inflammatory activity. Apolipoprotein-E (ApoE) is strongly associated with atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the therapeutic effect of β-OHB in the brain and the aorta of high-fat diet (HFD)-fed ApoE-deficient mice. We found in Apo-E deficient mice that β-OHB attenuated lipid deposition in the choroid plexus (ChP) and decreased amyloid plaque in the substantia nigra pars compacta. We also found decreased CD68-positive macroglia infiltration of the ChP in β-OHB-treated ApoE-deficient mice. β-OHB treatment ameliorated IgG extravasation into the hippocampal region of the brain. In vitro study using ChP mice cell line revealed that β-OHB attenuated oxidized low-density lipoprotein-induced ApoE-specific differentially expressed inflammatory ChP genes. Treatment with β-OHB reduced aortic plaque formation without affecting blood lipid profiles and decreased serum production of resistin, a well-established risk factor for both AD and atherosclerosis. Thus, the current study suggests and describes the therapeutic potential of β-OHB for the treatment of AD and atherosclerosis. |
| Volume | 12(2) |
| Published | 2020-2-13 |
| DOI | 10.3390/nu12020471 |
| PII | nu12020471 |
| PMID | 32069870 |
| PMC | PMC7071244 |
| MeSH | 3-Hydroxybutyric Acid / pharmacology* Alzheimer Disease / drug therapy* Alzheimer Disease / etiology Animals Anti-Inflammatory Agents / pharmacology* Aorta / drug effects Apolipoproteins E / deficiency Atherosclerosis / drug therapy* Atherosclerosis / etiology Brain / drug effects Diet, High-Fat Disease Models, Animal Disease Progression Male Mice Mice, Inbred C57BL Mice, Knockout Plaque, Amyloid |
| IF | 4.546 |
| Times Cited | 0 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 51 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ECPC-4(RCB1287) |