論文 - 詳細
| RRC ID | 58774 |
|---|---|
| 著者 | Phan TKT, Shahbazzadeh F, Kihara T. |
| タイトル | Alpha-mangostin reduces mechanical stiffness of various cells. |
| ジャーナル | Hum Cell |
| Abstract |
Alpha-mangostin (α-mangostin) has been identified as a naturally occurring compound with potential anticancer properties. It can induce apoptosis and inhibit the growth and metastasis of cancer cells. Moreover, α-mangostin reduces the mechanical stiffness of lung cancer cells. The objective of this study was to determine the effect of α-mangostin on the mechanical stiffness of various cells, as well as cell viability. The following cell types were examined: human fibroblast TIG-1 cells, human cancerous HeLa cells, human embryonic kidney HEK293 cells, mouse macrophage RAW 264.7 cells, and human myeloblasts KG-1 cells. Cells were treated with α-mangostin, and then examined for cell viability, actin cytoskeletal structures, and surface mechanical stiffness using atomic force microscopy. α-Mangostin demonstrated cytotoxicity against TIG-1, HeLa, HEK293, and KG-1 cells, but not against RAW 264.7 cells. The cytotoxic effect of α-mangostin varies according to cell type. On the other hand, α-mangostin reduced the mechanical stiffness of all cell types, including RAW 264.7 cells. Upon treatment with α-mangostin, F-actin was slightly reduced but the actin cytoskeletal structures were little altered in these cells. Thus, reducing mechanical stiffness of animal cells is an inherent effect of α-mangostin. Our results show that α-mangostin is a naturally occurring compound with potential to change the actin cytoskeletal micro-structures and reduce the surface stiffness of various cells. |
| 巻・号 | 33(2) |
| ページ | 347-355 |
| 公開日 | 2020-4-1 |
| DOI | 10.1007/s13577-020-00330-0 |
| PII | 10.1007/s13577-020-00330-0 |
| PMID | 32078151 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / pharmacology* Biomechanical Phenomena / drug effects* HeLa Cells Humans Mice Neoplasms / pathology* RAW 264.7 Cells Xanthones / pharmacology* |
| IF | 2.333 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |