| RRC ID |
58782
|
| 著者 |
Kuchitsu Y, Nagashio R, Igawa S, Kusuhara S, Tsuchiya B, Ichinoe M, Satoh Y, Naoki K, Murakumo Y, Saegusa M, Sato Y.
|
| タイトル |
TRAP1 is a predictive biomarker of platinum-based adjuvant chemotherapy benefits in patients with resected lung adenocarcinoma.
|
| ジャーナル |
Biomed Res
|
| Abstract |
Platinum-based adjuvant chemotherapy after complete resection has become a standard treatment for patients with stage II to IIIA non-small cell lung cancer; however, not all patients exhibit survival benefits. Therefore, the development of predictive biomarkers for selecting a subgroup of patients who may show improved survival after these treatments is important. Among the 42 proteins identified here using a proteomics analysis that were recognized by autoantibodies in pretreated sera from patients with lung adenocarcinoma who received platinum-based adjuvant chemotherapy, the tumor necrosis factor-receptor-associated protein 1 (TRAP1) was detected in patients with a short disease-free survival. TRAP1 expression was immunohistochemically analyzed in 64 patients with completely resected stage II and IIIA lung adenocarcinoma treated with platinum-based adjuvant chemotherapy. TRAP1 expression was significantly associated with higher p-TNM stage (P = 0.005) and lymph node metastasis (P = 0.017). Moreover, TRAP1 expression was significantly correlated with a shorter disease-free survival (P = 0.028). Furthermore, TRAP1-siRNA-treated LC-2/ad cells derived from lung adenocarcinoma exhibited significantly reduced proliferation and increased sensitivity to cisplatin. These results suggest that TRAP1 expression is a valuable biomarker for predicting the poor survival of platinum-based adjuvant chemotherapy in patients with resected lung adenocarcinoma.
|
| 巻・号 |
41(1)
|
| ページ |
53-65
|
| 公開日 |
2020-1-1
|
| DOI |
10.2220/biomedres.41.53
|
| PMID |
32092740
|
| MeSH |
A549 Cells
Adenocarcinoma of Lung / drug therapy*
Adenocarcinoma of Lung / surgery*
Adult
Aged
Biomarkers, Tumor / metabolism*
Chemotherapy, Adjuvant / methods*
Cisplatin / pharmacology
Disease-Free Survival
Drug Resistance, Neoplasm
Electrophoresis, Gel, Two-Dimensional
Female
HSP90 Heat-Shock Proteins / metabolism*
Humans
Immunohistochemistry
Lung Neoplasms / drug therapy*
Lung Neoplasms / surgery*
Lymphatic Metastasis
Male
Middle Aged
Proteomics / methods
RNA, Small Interfering / metabolism
Retrospective Studies
|
| IF |
1.429
|
| 引用数 |
1
|
| リソース情報 |
| ヒト・動物細胞 |
A549, LC-2/ad(RCB0440) |
