| RRC ID |
58792
|
| 著者 |
Imato K, Nagata K, Watanabe R, Takeda N.
|
| タイトル |
Cell adhesion control by photoinduced LCST shift of PNIPAAm-based brush scaffolds.
|
| ジャーナル |
J Mater Chem B
|
| Abstract |
Poly(N-isopropylacrylamide) (PNIPAAm)-brush substrates are one of the most successful dynamic scaffolds for thermally controlling cell adhesion. Endowing substrates with photocontrollability promises further development and applications in the biomedical and bioengineering fields. In this study, we developed photoresponsive PNIPAAm copolymers by incorporation of spiropyran into the polymer chain, enabling the photoinduced shift of the lower critical solution temperatures. Their brush substrates were fabricated in a simple, facile grafting-to manner. Co-grafting with non-cell-adhesive poly(ethylene glycol) enhanced the modulation of surface chemical properties upon photostimulation; it enabled significant photocontrol of cell adhesion of several types with keeping culture temperature constant.
|
| 巻・号 |
8(12)
|
| ページ |
2393-2399
|
| 公開日 |
2020-3-25
|
| DOI |
10.1039/c9tb02958c
|
| PMID |
32108194
|
| MeSH |
Acrylic Resins / chemistry
Acrylic Resins / pharmacology*
Animals
Cell Adhesion / drug effects
Cell Line
Mice
NIH 3T3 Cells
Particle Size
Photochemical Processes
Solutions
Surface Properties
Temperature*
Ultraviolet Rays*
|
| IF |
5.047
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
C2C12(RCB0987) |
