論文 - 詳細
| RRC ID | 58929 |
|---|---|
| 著者 | Maeda H, Murata K, Sakuma N, Takei S, Yamazaki A, Karim MR, Kawata M, Hirose S, Kawagishi-Kobayashi M, Taniguchi Y, Suzuki S, Sekino K, Ohshima M, Kato H, Yoshida H, Tozawa Y. |
| タイトル | A rice gene that confers broad-spectrum resistance to β-triketone herbicides. |
| ジャーナル | Science |
| Abstract |
The genetic variation of rice cultivars provides a resource for further varietal improvement through breeding. Some rice varieties are sensitive to benzobicyclon (BBC), a β-triketone herbicide that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD). Here we identify a rice gene, HIS1 (HPPD INHIBITOR SENSITIVE 1), that confers resistance to BBC and other β-triketone herbicides. We show that HIS1 encodes an Fe(II)/2-oxoglutarate-dependent oxygenase that detoxifies β-triketone herbicides by catalyzing their hydroxylation. Genealogy analysis revealed that BBC-sensitive rice variants inherited a dysfunctional his1 allele from an indica rice variety. Forced expression of HIS1 in Arabidopsis conferred resistance not only to BBC but also to four additional β-triketone herbicides. HIS1 may prove useful for breeding herbicide-resistant crops. |
| 巻・号 | 365(6451) |
| ページ | 393-396 |
| 公開日 | 2019-7-26 |
| DOI | 10.1126/science.aax0379 |
| PII | 365/6451/393 |
| PMID | 31346065 |
| MeSH | 4-Hydroxyphenylpyruvate Dioxygenase / antagonists & inhibitors Bridged Bicyclo Compounds / chemistry* Bridged Bicyclo Compounds / pharmacology* Genes, Plant* Herbicide Resistance / genetics* Ketones / chemistry Oryza / drug effects* Oryza / genetics* Oxygenases / genetics* Sulfones / chemistry* Sulfones / pharmacology* |
| IF | 41.846 |
| 引用数 | 7 |
| リソース情報 | |
| オオムギ | 完全長クローンFLbaf87j22,FLbaf135n09 |