| RRC ID |
58958
|
| 著者 |
Hanashiro J, Muraosa Y, Toyotome T, Hirose K, Watanabe A, Kamei K.
|
| タイトル |
Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Schizophyllum commune is a ubiquitous basidiomycetous fungus typically found across the world, which has been detected in indoor and outdoor air. Some studies indicated that sensitization to S. commune is correlated with asthma severity in patients. Patients with chronic severe or acute fatal asthma have neutrophil-dominant airway inflammation. We hypothesized that S. commune can exacerbate asthma. To test this hypothesis, we evaluated the direct immunomodulatory activities of S. commune in allergic airway inflammation induced by non-fungal sensitization. Ovalbumin (OVA)-induced asthma model mice were generated using wild-type (WT) and Il-17a-/-Il-17f-/- mice that were intratracheally exposed to S. commune, then immune responses in the lungs were assessed after 24 h. Intratracheal administration of S. commune in OVA-induced asthma model mice enhanced neutrophilic airway inflammation, increased the mRNA expression of CXCL1 and CXCL2 in the lungs, and provoked IL-17A, and IL-17F production in BAL fluid. In addition, neutrophilic airway inflammation was significantly inhibited in Il-17a-/-Il-17f-/- mice compared with those found in WT mice. We demonstrated that S. commune induces neutrophilic airway inflammation in OVA-induced asthma model mice, and IL-17A and IL-17F had central roles in this activity. As S. commune inhabits the general environment, including indoor and outdoor air, our results suggested that S. commune is a causative agent of asthma exacerbation. This study has provided clues regarding the mechanisms behind fungi and asthma exacerbation.
|
| 巻・号 |
9(1)
|
| ページ |
19321
|
| 公開日 |
2019-12-18
|
| DOI |
10.1038/s41598-019-55836-x
|
| PII |
10.1038/s41598-019-55836-x
|
| PMID |
31852931
|
| PMC |
PMC6920419
|
| MeSH |
Animals
Asthma / immunology*
Asthma / microbiology*
Disease Models, Animal
Female
Interleukin-17 / immunology*
Mice, Inbred C57BL
Neutrophils / pathology*
Ovalbumin
Pneumonia / microbiology*
Schizophyllum / physiology*
Th17 Cells / immunology
|
| IF |
3.998
|
| 引用数 |
0
|
| リソース情報 |
| 病原真核微生物 |
IFM 47009 |
