Reference - Detail
| RRC ID | 58967 |
|---|---|
| Author | Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Fukushima S, Ihn H. |
| Title | Fungal melanonychia caused by Candida parapsilosis successfully treated with oral fosravuconazole. |
| Journal | J Dermatol |
| Abstract |
A 73-year-old healthy woman noticed black pigmentation on both thumbnails for 6 years. Upon her visit to our clinic, she had pigmented onychomycosis with onycholysis in the distal area. There was no evidence of paronychia. Direct microscopy using Zoomblue™ and histopathological examination showed aggregated blastoconidia. Fontana-Masson staining confirmed fungal melanin production. A combination of morphological features and genetic testing identified the isolates as Candida parapsilosis. Fungal melanonychia due to C. parapsilosis is rare, with only six cases reported since 1979. The minimum inhibitory concentration of the isolates was 0.25 μg/mL for itraconazole, less than 0.03 μg/mL for ravuconazole and 2.0 μg/mL for terbinafine. Both oral terbinafine treatment and itraconazole pulse therapy performed for 6 months were unsuccessful. The disease was ultimately cured with a 3-month treatment of oral fosravuconazole. |
| Volume | 46(10) |
| Pages | 911-913 |
| Published | 2019-10-1 |
| DOI | 10.1111/1346-8138.15024 |
| PMID | 31342551 |
| MeSH | Administration, Oral Aged Antifungal Agents / administration & dosage Candida parapsilosis / isolation & purification* Female Hand Dermatoses / diagnosis Hand Dermatoses / drug therapy* Hand Dermatoses / microbiology Humans Melanosis / diagnosis Melanosis / drug therapy* Melanosis / microbiology Onychomycosis / diagnosis Onychomycosis / drug therapy* Onychomycosis / microbiology Prodrugs / administration & dosage Thiazoles / administration & dosage* Treatment Outcome Triazoles / administration & dosage* |
| IF | 3.377 |
| Times Cited | 1 |
| Resource | |
| Pathogenic eukaryotic microorganisms | IFM 65757 |