論文 - 詳細
| RRC ID | 58971 |
|---|---|
| 著者 | Kurosawa S, Sekiya N, Doki N, Yaguchi T, Kishida Y, Nagata A, Yamada Y, Konishi T, Kaito S, Yoshifuji K, Shirane S, Uchida T, Inamoto K, Toya T, Igarashi A, Najima Y, Muto H, Kobayashi T, Kakihana K, Sakamaki H, Ohashi K. |
| タイトル | The emergence of rare nocardiosis following allogeneic hematopoietic stem cell transplantation in the era of molecular taxonomy. |
| ジャーナル | Int J Infect Dis |
| Abstract |
OBJECTIVE:The purpose of this study was to describe the clinical features of nocardiosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on new Nocardia species. METHODS:We retrospectively reviewed data from patients with nocardiosis after allo-HSCT treated at our hospital and documented cases in the medical literature. RESULTS:Fifty-seven cases were identified from our institution and the literature review. Although 51 patients (89.5%) responded to initial treatment, 28 (49.1%) patients were switched over to other treatment regimens due to the recurrence of nocardiosis or adverse events of antimicrobials. Nocardiosis-attributed mortality occurred in ten patients (17.5%). Antimicrobial susceptibilities varied among intra- and inter-species except linezolid (LZD). In the present study, five species were newly discovered after 2000, including N. cyriacigeorgica, N. veterana, N. abscessus, N. aobensis, and N. mexicana. All isolates of N. cyriacigeorgica, N. veterana, N. abscessus, and N. aobensis were sensitive to trimethoprim/sulfamethoxazole, amikacin (AMK), imipenem (IPM), and LZD; however, N. mexicana was resistant to AMK and IPM. CONCLUSION:Newly identified Nocardia species have various antimicrobial susceptibility patterns. Long-term maintenance therapy could be challenging due to the adverse events of antimicrobials, especially in the allo-HSCT setting. Prudent evaluation is crucial for selecting a second-line or further treatment options. |
| 巻・号 | 89 |
| ページ | 154-162 |
| 公開日 | 2019-12-1 |
| DOI | 10.1016/j.ijid.2019.10.003 |
| PII | S1201-9712(19)30395-9 |
| PMID | 31605809 |
| MeSH | Anti-Bacterial Agents / therapeutic use Hematopoietic Stem Cell Transplantation / adverse effects* Humans Nocardia / classification Nocardia / drug effects Nocardia / genetics Nocardia / isolation & purification* Nocardia Infections / drug therapy Nocardia Infections / etiology* Nocardia Infections / microbiology Postoperative Complications / drug therapy Postoperative Complications / etiology* Postoperative Complications / microbiology Retrospective Studies Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use |
| IF | 3.202 |
| 引用数 | 1 |
| リソース情報 | |
| 病原真核微生物 | IFM 10152 |