RRC ID 58974
Author Toyotome T, Saito S, Koshizaki Y, Komatsu R, Matsuzawa T, Yaguchi T.
Title Prospective survey of Aspergillus species isolated from clinical specimens and their antifungal susceptibility: A five-year single-center study in Japan.
Journal J Infect Chemother
Abstract Aspergillus fumigatus is the most prevalent species that causes aspergillosis. A. fumigatus strains with tandem repeats in the cyp51A promoter have emerged in the environment. Aspergillus species other than A. fumigatus have also been recognized as causative agents of aspergillosis; however, they show lower susceptibility to antifungals compared with A. fumigatus. Therefore, it is important to precisely identify Aspergillus species and determine their antifungal susceptibility. Herein, we collected 119 mold strains isolated from clinical specimens collected at a hospital between November 2013 and December 2018. The collected strains were identified by sequencing several regions, including internal transcribed spacers, and determined their susceptibility to the antifungals itraconazole, voriconazole, and amphotericin B. Of 119 strains, 107 were Aspergillus species, which were identified as A. fumigatus (67), Aspergillus section Nigri (21), A. flavus (7), A. terreus (6), and A. nidulans (6). In Aspergillus section Nigri, the number of A. niger was less than the number of A. welwitschiae and A. tubingensis. Two azole-resistant A. fumigatus samples were included among the isolates. Four of the eight A. tubingensis isolates showed less susceptibility to voriconazole; however, all isolates of A. niger and A. welwitschiae were susceptible to itraconazole and voriconazole. Because of lack of susceptibility data for non-fumigatus Aspergillus and an increasing frequency of antifungal resistance among A. fumigatus, our data along with further surveillance may contribute to determining the frequency and susceptibility of Aspergillus spp. clinical isolates in Japan.
Volume 26(2)
Pages 321-323
Published 2020-2-1
DOI 10.1016/j.jiac.2019.09.002
PII S1341-321X(19)30272-7
PMID 31564504
MeSH Antifungal Agents / pharmacology* Aspergillosis / microbiology* Aspergillus / classification Aspergillus / drug effects* Aspergillus / isolation & purification* Drug Resistance, Fungal Humans Japan Microbial Sensitivity Tests
IF 1.539
Times Cited 1
Pathogenic eukaryotic microorganisms IFM 64159 (=OKH 31), IFM 64160 (= OKH 34), IFM 64732 (= OKH 50)