Reference - Detail
| RRC ID | 59015 |
|---|---|
| Author | Matsumoto Y, Takahashi M, Sekimizu K. |
| Title | Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells. |
| Journal | Drug Discov Ther |
| Abstract |
Natto is a well-known traditional Japanese food produced by fermenting soybeans with Bacillus subtilis var natto. Here we found that the water-soluble viscous fraction of natto inhibits sucrose- or glucose-induced hyperglycemia in silkworms. The water-soluble viscous fraction treated with DNase I, RNase A, and proteinase K, followed by phenol extraction also suppressed sucrose-induced hyperglycemia in silkworms. The enzyme-treated polysaccharide fraction of natto inhibits glucose uptake by Caco-2 cells, human intestinal epithelial cells. These findings suggest that the polysaccharide components of natto selected on the basis of their suppressive effects on sucrose-induced hyperglycemia in silkworms inhibit glucose uptake by human intestinal cells. |
| Volume | 14(1) |
| Pages | 8-13 |
| Published | 2020-1-1 |
| DOI | 10.5582/ddt.2020.01002 |
| PMID | 32147629 |
| MeSH | Animals Bacillus subtilis* Bombyx Caco-2 Cells Fermented Foods* / microbiology Glucose / metabolism* Humans Hyperglycemia* / therapy Intestinal Mucosa / metabolism* Polysaccharides / metabolism Polysaccharides / pharmacology* Soy Foods Sucrose |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Silkworms | |