RRC ID 59046
著者 Hashimoto S, Tanaka E, Ueyama M, Terada S, Inao T, Kaji Y, Yasuda T, Hajiro T, Nakagawa T, Noma S, Honjo G, Kobashi Y, Abe N, Kamei K, Taguchi Y.
タイトル A case report of pulmonary Botrytis sp. infection in an apparently healthy individual.
ジャーナル BMC Infect Dis
Abstract BACKGROUND:Botrytis species are well known fungal pathogens of various plants but have not been reported as human pathogens, except as allergenic precipitants of asthma and hypersensitivity pneumonitis.
CASE PRESENTATION:The asymptomatic patient was referred because of a nodule revealed by chest X-ray. Computed tomography (CT) showed a cavitary nodule in the right upper lobe of the lung. He underwent wedge resection of the nodule, which revealed necrotizing granulomas and a fungus ball containing Y-shaped filamentous fungi, which was confirmed histopathologically. Culture of the specimen yielded white to grayish cotton-like colonies with black sclerotia. We performed multilocus gene sequence analyses including three single-copy nuclear DNA genes encoding glyceraldehyde-3-phosphate dehydrogenase, heat-shock protein 60, and DNA-dependent RNA polymerase subunit II. The analyses revealed that the isolate was most similar to Botrytis elliptica. To date, the pulmonary Botrytis sp. infection has not recurred after lung resection and the patient did not require any additional medication.
CONCLUSIONS:We report the first case of an immunocompetent patient with pulmonary Botrytis sp. infection, which has not recurred after lung resection without any additional medication. Precise evaluation is necessary for the diagnosis of pulmonary Botrytis infection because it is indistinguishable from other filamentous fungi both radiologically and by histopathology. The etiology and pathophysiology of pulmonary Botrytis infection remains unclear. Further accumulation and analysis of Botrytis cases is warranted.
巻・号 19(1)
ページ 684
公開日 2019-8-2
DOI 10.1186/s12879-019-4319-2
PII 10.1186/s12879-019-4319-2
PMID 31375066
PMC PMC6679495
MeSH Biopsy Botrytis / genetics Botrytis / pathogenicity* Fungal Proteins / genetics Humans Lung Diseases, Fungal / diagnostic imaging* Lung Diseases, Fungal / microbiology* Lung Diseases, Fungal / pathology Lung Diseases, Fungal / surgery Male Middle Aged Tomography, X-Ray Computed
IF 2.688
引用数 0
リソース情報
病原真核微生物 IFM 62716