論文 - 詳細
| RRC ID | 59062 |
|---|---|
| 著者 | Warnhoff K, Ruvkun G. |
| タイトル | Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. |
| ジャーナル | Nat Chem Biol |
| Abstract |
The kingdoms of life share many small molecule cofactors and coenzymes. Molybdenum cofactor (Moco) is synthesized by many archaea, bacteria, and eukaryotes, and is essential for human development. The genome of Caenorhabditis elegans contains all of the Moco biosynthesis genes, and surprisingly these genes are not essential if the animals are fed a bacterial diet that synthesizes Moco. C. elegans lacking both endogenous Moco synthesis and dietary Moco from bacteria arrest development, demonstrating interkingdom Moco transfer. Our screen of Escherichia coli mutants identifies genes necessary for synthesis of bacterial Moco or transfer to C. elegans. Developmental arrest of Moco-deficient C. elegans is caused by loss of sulfite oxidase, a Moco-requiring enzyme, and is suppressed by mutations in either C. elegans cystathionine gamma-lyase or cysteine dioxygenase, blocking toxic sulfite production from cystathionine. Thus, we define the genetic pathways for an interkingdom dialogue focused on sulfur homeostasis. |
| 巻・号 | 15(5) |
| ページ | 480-488 |
| 公開日 | 2019-5-1 |
| DOI | 10.1038/s41589-019-0249-y |
| PII | 10.1038/s41589-019-0249-y |
| PMID | 30911177 |
| PMC | PMC6470025 |
| MeSH | Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / metabolism* Coenzymes / metabolism* Homeostasis Metalloproteins / metabolism* Pteridines / metabolism* Sulfites / metabolism* Sulfites / toxicity |
| IF | 12.154 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | Keio collection |