論文 - 詳細
| RRC ID | 59102 |
|---|---|
| 著者 | Li Y, Zhang F, Jiang N, Liu T, Shen J, Zhang J. |
| タイトル | Decapentaplegic signaling regulates Wingless ligand production and target activation during Drosophila wing development. |
| ジャーナル | FEBS Lett |
| Abstract |
The Decapentaplegic (Dpp) and Wingless (Wg) signaling pathways are essential for animal development. However, how these two signals are integrated in distinct tissues is not fully understood. Here, we describe a novel mode of Dpp-Wg crosstalk during Drosophila wing development. We show that the canonical Dpp signaling is required for Wg target gene activation. In addition, Dpp signaling inhibits the transcription of wg through the schnurri (shn) repressor complex. A Dpp-responsive shn/pMad/Med silencer element (SSE) is identified in the genomic loci of the wg gene. ChIP analysis suggests that shn interacts with this element in vivo. Our findings support a model in which Dpp signaling plays a dual role in transcriptional regulation of both the wg gene and downstream targets. |
| 巻・号 | 594(7) |
| ページ | 1176-1186 |
| 公開日 | 2020-4-1 |
| DOI | 10.1002/1873-3468.13713 |
| PMID | 31814119 |
| MeSH | Animals Drosophila Proteins / biosynthesis Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism* Gene Expression Regulation, Developmental Ligands Signal Transduction* Transcription, Genetic Wings, Animal / growth & development* Wings, Animal / metabolism* Wnt1 Protein / biosynthesis Wnt1 Protein / genetics Wnt1 Protein / metabolism* |
| IF | 3.057 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#111141 DGRC#114393 DGRC#120640 |