論文 - 詳細
| RRC ID | 59109 |
|---|---|
| 著者 | Ishimoto H, Kamikouchi A. |
| タイトル | A Feedforward Circuit Regulates Action Selection of Pre-mating Courtship Behavior in Female Drosophila. |
| ジャーナル | Curr Biol |
| Abstract |
In the early phase of courtship, female fruit flies exhibit an acute rejection response to avoid unfavorable mating. This pre-mating rejection response is evolutionarily paralleled across species, but the molecular and neuronal basis of that behavior is unclear. Here, we show that a putative incoherent feedforward circuit comprising ellipsoid body neurons, cholinergic R4d, and its repressor GABAergic R2/R4m neurons regulates the pre-mating rejection response in the virgin female Drosophila melanogaster. Both R4d and R2/R4m are positively regulated, via specific dopamine receptors, by a subset of neurons in the dopaminergic PPM3 cluster. Genetic deprivation of GABAergic signal via GABAA receptor RNA interference in this circuit induces a massive rejection response, whereas activation of GABAergic R2/R4m or suppression of cholinergic R4d increases receptivity. Moreover, glutamatergic signaling via N-methyl-d-aspartate receptors induces NO-mediated retrograde regulation potentially from R4d to R2/R4m, likely providing flexible control of the behavioral switching from rejection to acceptance. Our study elucidates the molecular and neural mechanisms regulating the behavioral selection process of the pre-mating female. |
| 巻・号 | 30(3) |
| ページ | 396-407.e4 |
| 公開日 | 2020-2-3 |
| DOI | 10.1016/j.cub.2019.11.065 |
| PII | S0960-9822(19)31567-2 |
| PMID | 31902724 |
| MeSH | Animals Cell Communication Courtship Drosophila melanogaster / physiology* Female GABAergic Neurons / physiology Neurons / physiology* Sexual Behavior, Animal / physiology* |
| IF | 9.601 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#103898 |