論文 - 詳細
| RRC ID | 59113 |
|---|---|
| 著者 | Li Q, DeBeaubien NA, Sokabe T, Montell C. |
| タイトル | Temperature and Sweet Taste Integration in Drosophila. |
| ジャーナル | Curr Biol |
| Abstract |
Sugar-containing foods offered at cooler temperatures tend to be less appealing to many animals. However, the mechanism through which the gustatory system senses thermal input and integrates temperature and chemical signals to produce a given behavioral output is poorly understood. To study this fundamental problem, we used the fly, Drosophila melanogaster. We found that the palatability of sucrose is strongly reduced by modest cooling. Using Ca2+ imaging and electrophysiological recordings, we demonstrate that bitter gustatory receptor neurons (GRNs) and mechanosensory neurons (MSNs) are activated by slight cooling, although sugar neurons are insensitive to the same mild stimulus. We found that a rhodopsin, Rh6, is expressed and required in bitter GRNs for cool-induced suppression of sugar appeal. Our findings reveal that the palatability of sugary food is reduced by slightly cool temperatures through different sets of thermally activated neurons, one of which depends on a rhodopsin (Rh6) for cool sensation. |
| 巻・号 | 30(11) |
| ページ | 2051-2067.e5 |
| 公開日 | 2020-6-8 |
| DOI | 10.1016/j.cub.2020.03.066 |
| PII | S0960-9822(20)30436-X |
| PMID | 32330421 |
| PMC | PMC7329267 |
| MeSH | Animals Cold Temperature* Drosophila Proteins / metabolism Drosophila melanogaster / physiology* Female Gene Expression Male Neurons / physiology* Rhodopsin / metabolism Taste Perception / physiology* |
| IF | 9.601 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 38 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109600 |