Reference - Detail
| RRC ID | 59116 |
|---|---|
| Author | Leung NY, Thakur DP, Gurav AS, Kim SH, Di Pizio A, Niv MY, Montell C. |
| Title | Functions of Opsins in Drosophila Taste. |
| Journal | Curr Biol |
| Abstract |
Rhodopsin is a light receptor comprised of an opsin protein and a light-sensitive retinal chromophore. Despite more than a century of scrutiny, there is no evidence that opsins function in chemosensation. Here, we demonstrate that three Drosophila opsins, Rh1, Rh4, and Rh7, are needed in gustatory receptor neurons to sense a plant-derived bitter compound, aristolochic acid (ARI). The gustatory requirements for these opsins are light-independent and do not require retinal. The opsins enabled flies to detect lower concentrations of aristolochic acid by initiating an amplification cascade that includes a G-protein, phospholipase Cβ, and the TRP channel, TRPA1. In contrast, responses to higher levels of the bitter compound were mediated through direct activation of TRPA1. Our study reveals roles for opsins in chemosensation and raise questions concerning the original roles for these classical G-protein-coupled receptors. |
| Volume | 30(8) |
| Pages | 1367-1379.e6 |
| Published | 2020-4-20 |
| DOI | 10.1016/j.cub.2020.01.068 |
| PII | S0960-9822(20)30112-3 |
| PMID | 32243853 |
| PMC | PMC7252503 |
| MeSH | Animals Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Male Opsins / genetics* Opsins / metabolism Random Allocation Taste / physiology* Taste Perception / physiology* |
| IF | 9.601 |
| Times Cited | 1 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 62 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#109600 |