Reference - Detail
| RRC ID | 59141 |
|---|---|
| Author | Ramaekers A, Claeys A, Kapun M, Mouchel-Vielh E, Potier D, Weinberger S, Grillenzoni N, Dardalhon-Cuménal D, Yan J, Wolf R, Flatt T, Buchner E, Hassan BA. |
| Title | Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs. |
| Journal | Dev Cell |
| Abstract |
Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non-visual fields. We discover that changes in the temporal regulation of the highly conserved eyeless/Pax6 gene expression during development is a conserved mechanism for sensory trade-offs within and between Drosophila species. We identify a natural single nucleotide polymorphism in the cis-regulatory region of eyeless in a binding site of its repressor Cut that is sufficient to alter its temporal regulation and eye size. Because eyeless/Pax6 is a conserved regulator of head sensory placode subdivision, we propose that its temporal regulation is key to define the relative size of head sensory organs. |
| Volume | 50(6) |
| Pages | 780-792.e7 |
| Published | 2019-9-23 |
| DOI | 10.1016/j.devcel.2019.07.027 |
| PII | S1534-5807(19)30658-6 |
| PMID | 31447264 |
| MeSH | Animals Binding Sites Biological Evolution* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics* Enhancer Elements, Genetic / genetics Eye / anatomy & histology Eye / metabolism Female Gene Expression Regulation, Developmental* Geography Head Nucleotides / genetics Organ Size / genetics Polymorphism, Single Nucleotide / genetics Sense Organs / metabolism* Time Factors |
| IF | 10.092 |
| Times Cited | 8 |
| Resource | |
| Drosophila | DGRC#105668 DGRC#104957 DGRC#103421 |