RRC ID 59162
Author Zhao B, Sun J, Zhang X, Mo H, Niu Y, Li Q, Wang L, Zhong Y.
Title Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila.
Journal Nat Commun
Abstract It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrieved if synaptic transmission from any one of these centres is blocked, with effects similar to those of altered encoding context during retrieval. The present study provides strong evidence that long-term memory can be formed easily without the need for consolidation.
Volume 10(1)
Pages 4550
Published 2019-10-7
DOI 10.1038/s41467-019-12436-7
PII 10.1038/s41467-019-12436-7
PMID 31591396
PMC PMC6779902
MeSH Animals Animals, Genetically Modified Dopaminergic Neurons / metabolism Dopaminergic Neurons / physiology* Drosophila Proteins / biosynthesis* Drosophila Proteins / genetics Female Luminescent Proteins / genetics Luminescent Proteins / metabolism Memory, Long-Term / physiology* Microscopy, Confocal Mushroom Bodies / cytology Mushroom Bodies / metabolism Mushroom Bodies / physiology* Neural Pathways / physiology Odorants Synaptic Transmission / physiology
IF 11.878
Times Cited 4
Resource
Drosophila DGRC#112440 DGRC#104359 DGRC#113625 DGRC#104219