| RRC ID |
59162
|
| 著者 |
Zhao B, Sun J, Zhang X, Mo H, Niu Y, Li Q, Wang L, Zhong Y.
|
| タイトル |
Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila.
|
| ジャーナル |
Nat Commun
|
| Abstract |
It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrieved if synaptic transmission from any one of these centres is blocked, with effects similar to those of altered encoding context during retrieval. The present study provides strong evidence that long-term memory can be formed easily without the need for consolidation.
|
| 巻・号 |
10(1)
|
| ページ |
4550
|
| 公開日 |
2019-10-7
|
| DOI |
10.1038/s41467-019-12436-7
|
| PII |
10.1038/s41467-019-12436-7
|
| PMID |
31591396
|
| PMC |
PMC6779902
|
| MeSH |
Animals
Animals, Genetically Modified
Dopaminergic Neurons / metabolism
Dopaminergic Neurons / physiology*
Drosophila Proteins / biosynthesis*
Drosophila Proteins / genetics
Female
Luminescent Proteins / genetics
Luminescent Proteins / metabolism
Memory, Long-Term / physiology*
Microscopy, Confocal
Mushroom Bodies / cytology
Mushroom Bodies / metabolism
Mushroom Bodies / physiology*
Neural Pathways / physiology
Odorants
Synaptic Transmission / physiology
|
| IF |
12.121
|
| 引用数 |
4
|
| リソース情報 |
| ショウジョウバエ |
DGRC#112440
DGRC#104359
DGRC#113625
DGRC#104219 |
