RRC ID |
59163
|
Author |
Mohamed AAM, Retzke T, Das Chakraborty S, Fabian B, Hansson BS, Knaden M, Sachse S.
|
Title |
Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe.
|
Journal |
Nat Commun
|
Abstract |
Evaluating odor blends in sensory processing is a crucial step for signal recognition and execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have characterized the neural and behavioral correlates of mixture perception in the olfactory system of Drosophila. Mixtures of odors with opposing valences elicit strong inhibition in certain attractant-responsive input channels. This inhibition correlates with reduced behavioral attraction. We demonstrate that defined subsets of GABAergic interneurons provide the neuronal substrate of this computation at pre- and postsynaptic loci via GABAB- and GABAA receptors, respectively. Intriguingly, manipulation of single input channels by silencing and optogenetic activation unveils a glomerulus-specific crosstalk between the attractant- and repellent-responsive circuits. This inhibitory interaction biases the behavioral output. Such a form of selective lateral inhibition represents a crucial neuronal mechanism in the processing of conflicting sensory information.
|
Volume |
10(1)
|
Pages |
1201
|
Published |
2019-3-13
|
DOI |
10.1038/s41467-019-09069-1
|
PII |
10.1038/s41467-019-09069-1
|
PMID |
30867415
|
PMC |
PMC6416470
|
MeSH |
Animals
Animals, Genetically Modified
Arthropod Antennae / innervation
Behavior, Animal / physiology
Drosophila melanogaster / physiology*
Excitatory Postsynaptic Potentials / physiology
Female
GABAergic Neurons / physiology
Inhibitory Postsynaptic Potentials / physiology
Interneurons / physiology
Odorants*
Olfactory Bulb / physiology*
Olfactory Pathways / physiology*
Olfactory Perception / physiology*
Olfactory Receptor Neurons / physiology
Optogenetics
Receptors, Odorant / genetics
Receptors, Odorant / physiology
|
IF |
12.121
|
Times Cited |
8
|
Resource |
Drosophila |
DGRC#113080 |