論文 - 詳細
| RRC ID | 59173 |
|---|---|
| 著者 | Rozenfeld E, Lerner H, Parnas M. |
| タイトル | Muscarinic Modulation of Antennal Lobe GABAergic Local Neurons Shapes Odor Coding and Behavior. |
| ジャーナル | Cell Rep |
| Abstract |
In the antennal lobe (AL), the first olfactory relay of Drosophila, excitatory neurons are predominantly cholinergic. Ionotropic nicotinic receptors play a vital role in the effects of acetylcholine in the AL. However, the AL also has a high expression level of metabotropic muscarinic acetylcholine receptors type A (mAChRs-A). Nevertheless, the neurons expressing them and their role in the AL are unknown. Elucidating their function may reveal principles in olfactory modulation. Here, we show that mAChRs-A shape AL output and affect behavior. We localized mAChRs-A effects to a sub-population of GABAergic local neurons (iLNs), where they play a dual role: direct excitation of iLNs and stabilization of the synapse between receptor neurons and iLNs, which undergoes strong short-term depression. Our results reveal modulatory functions of the AL main excitatory neurotransmitter. Striking similarities to the mammalian olfactory system predict that mammalian glutamatergic metabotropic receptors could be associated with similar modulations. |
| 巻・号 | 29(10) |
| ページ | 3253-3265.e4 |
| 公開日 | 2019-12-3 |
| DOI | 10.1016/j.celrep.2019.10.125 |
| PII | S2211-1247(19)31458-5 |
| PMID | 31801087 |
| PMC | PMC6900217 |
| MeSH | Acetylcholine / metabolism Animals Cholinergic Agents / pharmacology Drosophila / drug effects Drosophila / metabolism* Drosophila Proteins / metabolism* Female GABAergic Neurons / drug effects GABAergic Neurons / metabolism* Male Odorants Olfactory Bulb / drug effects Olfactory Bulb / metabolism* Receptors, Muscarinic / metabolism* Receptors, Nicotinic / metabolism Smell / physiology Synapses / metabolism |
| IF | 8.109 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113080 DGRC#104198 |