論文 - 詳細
| RRC ID | 59174 |
|---|---|
| 著者 | Hudry B, de Goeij E, Mineo A, Gaspar P, Hadjieconomou D, Studd C, Mokochinski JB, Kramer HB, Plaçais PY, Preat T, Miguel-Aliaga I. |
| タイトル | Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation. |
| ジャーナル | Cell |
| Abstract |
Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate how gut-derived signals contribute to sex differences in whole-body physiology. We find that carbohydrate handling is male-biased in a specific portion of the intestine. In contrast to known sexual dimorphisms in invertebrates, the sex differences in intestinal carbohydrate metabolism are extrinsically controlled by the adjacent male gonad, which activates JAK-STAT signaling in enterocytes within this intestinal portion. Sex reversal experiments establish roles for this male-biased intestinal metabolic state in controlling food intake and sperm production through gut-derived citrate. Our work uncovers a male gonad-gut axis coupling diet and sperm production, revealing that metabolic communication across organs is physiologically important. The instructive role of citrate in inter-organ communication might be significant in more biological contexts than previously recognized. |
| 巻・号 | 178(4) |
| ページ | 901-918.e16 |
| 公開日 | 2019-8-8 |
| DOI | 10.1016/j.cell.2019.07.029 |
| PII | S0092-8674(19)30796-2 |
| PMID | 31398343 |
| PMC | PMC6700282 |
| MeSH | Animals Carbohydrate Metabolism / physiology* Citric Acid / metabolism Drosophila Proteins / metabolism Drosophila melanogaster / metabolism* Eating / physiology* Female Gene Expression Intestinal Mucosa / metabolism* Janus Kinases / metabolism Male RNA-Seq STAT Transcription Factors / metabolism Sex Characteristics* Signal Transduction Sperm Maturation / physiology* Sugars / metabolism Testis / metabolism |
| IF | 38.637 |
| 引用数 | 13 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 169 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 DGRC#103948 DGRC#112001 DGRC#112920 |