RRC ID 59174
Author Hudry B, de Goeij E, Mineo A, Gaspar P, Hadjieconomou D, Studd C, Mokochinski JB, Kramer HB, Plaçais PY, Preat T, Miguel-Aliaga I.
Title Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation.
Journal Cell
Abstract Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate how gut-derived signals contribute to sex differences in whole-body physiology. We find that carbohydrate handling is male-biased in a specific portion of the intestine. In contrast to known sexual dimorphisms in invertebrates, the sex differences in intestinal carbohydrate metabolism are extrinsically controlled by the adjacent male gonad, which activates JAK-STAT signaling in enterocytes within this intestinal portion. Sex reversal experiments establish roles for this male-biased intestinal metabolic state in controlling food intake and sperm production through gut-derived citrate. Our work uncovers a male gonad-gut axis coupling diet and sperm production, revealing that metabolic communication across organs is physiologically important. The instructive role of citrate in inter-organ communication might be significant in more biological contexts than previously recognized.
Volume 178(4)
Pages 901-918.e16
Published 2019-8-8
DOI 10.1016/j.cell.2019.07.029
PII S0092-8674(19)30796-2
PMID 31398343
PMC PMC6700282
MeSH Animals Carbohydrate Metabolism / physiology* Citric Acid / metabolism Drosophila Proteins / metabolism Drosophila melanogaster / metabolism* Eating / physiology* Female Gene Expression Intestinal Mucosa / metabolism* Janus Kinases / metabolism Male RNA-Seq STAT Transcription Factors / metabolism Sex Characteristics* Signal Transduction Sperm Maturation / physiology* Sugars / metabolism Testis / metabolism
IF 38.637
Times Cited 13
Drosophila DGRC#104055 DGRC#103948 DGRC#112001 DGRC#112920