Reference - Detail
| RRC ID | 59181 |
|---|---|
| Author | Blanco-Obregon D, Katz MJ, Durrieu L, Gándara L, Wappner P. |
| Title | Context-specific functions of Notch in Drosophila blood cell progenitors. |
| Journal | Dev Biol |
| Abstract |
Drosophila Larval hematopoiesis takes place at the lymph gland, where myeloid-like progenitors differentiate into Plasmatocytes and Crystal Cells, under regulation of conserved signaling pathways. It has been established that the Notch pathway plays a specific role in Crystal Cell differentiation and maintenance. In mammalian hematopoiesis, the Notch pathway has been proposed to fulfill broader functions, including Hematopoietic Stem Cell maintenance and cell fate decision in progenitors. In this work we describe different roles that Notch plays in the lymph gland. We show that Notch, activated by its ligand Serrate, expressed at the Posterior Signaling Center, is required to restrain Core Progenitor differentiation. We define a novel population of blood cell progenitors that we name Distal Progenitors, where Notch, activated by Serrate expressed in Lineage Specifying Cells at the Medullary Zone/Cortical Zone boundary, regulates a binary decision between Plasmatocyte and Crystal Cell fates. Thus, Notch plays context-specific functions in different blood cell progenitor populations of the Drosophila lymph gland. |
| Volume | 462(1) |
| Pages | 101-115 |
| Published | 2020-6-1 |
| DOI | 10.1016/j.ydbio.2020.03.018 |
| PII | S0012-1606(20)30106-8 |
| PMID | 32243888 |
| MeSH | Animals Blood Cells / cytology Cell Differentiation / physiology Cell Lineage Drosophila Proteins / metabolism Drosophila Proteins / physiology Drosophila melanogaster / metabolism Hematopoiesis / physiology Hematopoietic Stem Cells / cytology* Jagged-1 Protein / metabolism Larva / metabolism Lymph Nodes / metabolism* Receptors, Notch / metabolism* Receptors, Notch / physiology Signal Transduction / physiology |
| IF | 2.896 |
| Times Cited | 0 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#105442 |