RRC ID 59437
Author Anderson SM, Cheesman HK, Peterson ND, Salisbury JE, Soukas AA, Pukkila-Worley R.
Title The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans.
Journal PLoS Pathog
Abstract Fatty acids affect a number of physiological processes, in addition to forming the building blocks of membranes and body fat stores. In this study, we uncover a role for the monounsaturated fatty acid oleate in the innate immune response of the nematode Caenorhabditis elegans. From an RNAi screen for regulators of innate immune defense genes, we identified the two stearoyl-coenzyme A desaturases that synthesize oleate in C. elegans. We show that the synthesis of oleate is necessary for the pathogen-mediated induction of immune defense genes. Accordingly, C. elegans deficient in oleate production are hypersusceptible to infection with diverse human pathogens, which can be rescued by the addition of exogenous oleate. However, oleate is not sufficient to drive protective immune activation. Together, these data add to the known health-promoting effects of monounsaturated fatty acids, and suggest an ancient link between nutrient stores, metabolism, and host susceptibility to bacterial infection.
Volume 15(6)
Pages e1007893
Published 2019-6-1
DOI 10.1371/journal.ppat.1007893
PMID 31206555
PMC PMC6597122
MeSH Animals Bacterial Infections / immunology* Caenorhabditis elegans / immunology* Immunity, Innate / drug effects* Oleic Acids / immunology Oleic Acids / pharmacology*
IF 6.463
Times Cited 6
C.elegans tm331 tm2182