論文 - 詳細
| RRC ID | 59471 |
|---|---|
| 著者 | Chute CD, DiLoreto EM, Zhang YK, Reilly DK, Rayes D, Coyle VL, Choi HJ, Alkema MJ, Schroeder FC, Srinivasan J. |
| タイトル | Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in cell-to-cell signaling, as biogenic amines are not normally recruited for communication between separate individuals. Here, we show that in the nematode C. elegans, a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter, octopamine. Neuronal ablation, cell-specific genetic rescue, and calcium imaging show that tyra-2 expression in the nociceptive neuron, ASH, is necessary and sufficient to induce osas#9 avoidance. Ectopic expression in the AWA neuron, which is generally associated with attractive responses, reverses the response to osas#9, resulting in attraction instead of avoidance behavior, confirming that TYRA-2 partakes in the sensing of osas#9. The TYRA-2/osas#9 signaling system represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor. |
| 巻・号 | 10(1) |
| ページ | 3186 |
| 公開日 | 2019-7-18 |
| DOI | 10.1038/s41467-019-11240-7 |
| PII | 10.1038/s41467-019-11240-7 |
| PMID | 31320626 |
| PMC | PMC6639374 |
| MeSH | Animals Avoidance Learning / physiology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Communication / physiology* Nociceptors / metabolism Octopamine / metabolism* Receptors, Biogenic Amine / genetics Receptors, Biogenic Amine / metabolism* Signal Transduction |
| IF | 11.878 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1846 |