論文 - 詳細
| RRC ID | 59500 |
|---|---|
| 著者 | Haag A, Walser M, Henggeler A, Hajnal A. |
| タイトル | The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. |
| ジャーナル | Elife |
| Abstract |
The intracellular trafficking of growth factor receptors determines the activity of their downstream signaling pathways. Here, we show that the putative HSP-90 co-chaperone CHP-1 acts as a regulator of EGFR trafficking in C. elegans. Loss of chp-1 causes the retention of the EGFR in the ER and decreases MAPK signaling. CHP-1 is specifically required for EGFR trafficking, as the localization of other transmembrane receptors is unaltered in chp-1(lf) mutants, and the inhibition of hsp-90 or other co-chaperones does not affect EGFR localization. The role of the CHP-1 homolog CHORDC1 during EGFR trafficking is conserved in human cells. Analogous to C. elegans, the response of CHORDC1-deficient A431 cells to EGF stimulation is attenuated, the EGFR accumulates in the ER and ERK2 activity decreases. Although CHP-1 has been proposed to act as a co-chaperone for HSP90, our data indicate that CHP-1 plays an HSP90-independent function in controlling EGFR trafficking through the ER. |
| 巻・号 | 9 |
| 公開日 | 2020-2-13 |
| DOI | 10.7554/eLife.50986 |
| PII | 50986 |
| PMID | 32053105 |
| PMC | PMC7062474 |
| MeSH | Animals Caenorhabditis elegans / metabolism* ErbB Receptors / metabolism HSP90 Heat-Shock Proteins / metabolism Humans Phosphate-Binding Proteins / physiology* Protein Transport Signal Transduction* |
| IF | 7.551 |
| 引用数 | 0 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2277 |