論文 - 詳細
| RRC ID | 59530 |
|---|---|
| 著者 | Lee D, An SWA, Jung Y, Yamaoka Y, Ryu Y, Goh GYS, Beigi A, Yang JS, Jung GY, Ma DK, Ha CM, Taubert S, Lee Y, Lee SV. |
| タイトル | MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis. |
| ジャーナル | PLoS Biol |
| Abstract |
Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced longevity and proteostasis. We find that inhibition of mdt-15 prevents animals from living long at low temperatures. We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), at low temperatures. We then demonstrate that maintaining a high UFA/SFA ratio is essential for proteostasis at low temperatures. We show that dietary supplementation with a monounsaturated fatty acid, oleic acid (OA), substantially mitigates the short life span and proteotoxicity in mdt-15(-) animals at low temperatures. Thus, lipidostasis regulated by MDT-15 appears to be a limiting factor for proteostasis and longevity at low temperatures. Our findings highlight the crucial roles of lipid regulation in maintaining normal organismal physiology under different environmental conditions. |
| 巻・号 | 17(8) |
| ページ | e3000415 |
| 公開日 | 2019-8-1 |
| DOI | 10.1371/journal.pbio.3000415 |
| PII | PBIOLOGY-D-19-00761 |
| PMID | 31408455 |
| PMC | PMC6692015 |
| MeSH | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism* Cold Temperature Dietary Supplements Fatty Acid Desaturases / metabolism Homeostasis Lipid Metabolism Longevity / physiology* Oleic Acid / administration & dosage Proteostasis Transcription Factors / metabolism* Transcriptional Activation |
| IF | 8.386 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2182 tm331 tm3410 |